MovDisordV3, Main, Exploration, bibRecord, 000F96

Rivastigmine as Alternative Treatment for Refractory REM Behavior Disorder in Parkinson's Disease

Identifieur interne : 000F96 ( Main/Exploration ); précédent : 000F95; suivant : 000F97

Rivastigmine as Alternative Treatment for Refractory REM Behavior Disorder in Parkinson's Disease

Auteurs : Raffaella Di Giacopo [Italie] ; Alfonso Fasano [Italie] ; Davide Quaranta [Italie] ; Giacomo Della Marca [Italie] ; Francesco Bove [Italie] ; Anna Rita Bentivoglio [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0183686

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Rivastigmine, Traitement, Réfractaire, Comportement, Choline.

English descriptors

KwdEn :
- Behavior, Choline, Nervous system diseases, Parkinson disease, Refractory, Rivastigmine, Treatment.

Abstract

Background: We report on a double-blind, crossover pilot trial for the treatment of rapid eye movement behavior disorder (RBD) in 12 patients with Parkinson's disease in whom conventional therapy failed. Methods: We employed a patch of the cholinesterase inhibitor rivastigmine at a dose of 4.6 mg/24 hours for 3 weeks compared with placebo to reduce the frequency of RBD episodes. The number of RBD episodes was monitored by diaries of bed partners. Results: Rivastigmine was well tolerated in most patients, with minor side effects, mainly related to peripheral cholinergic action, and significantly reduced the mean frequency of RBD episodes during the observation time. Conclusions: The results of this pilot trial need to be confirmed by further studies on a larger number of patients.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: We report on a double-blind, crossover pilot trial for the treatment of rapid eye movement behavior disorder (RBD) in 12 patients with Parkinson's disease in whom conventional therapy failed. Methods: We employed a patch of the cholinesterase inhibitor rivastigmine at a dose of 4.6 mg/24 hours for 3 weeks compared with placebo to reduce the frequency of RBD episodes. The number of RBD episodes was monitored by diaries of bed partners. Results: Rivastigmine was well tolerated in most patients, with minor side effects, mainly related to peripheral cholinergic action, and significantly reduced the mean frequency of RBD episodes during the observation time. Conclusions: The results of this pilot trial need to be confirmed by further studies on a larger number of patients.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Rivastigmine as Alternative Treatment for Refractory REM Behavior Disorder in Parkinson's Disease

Rivastigmine as Alternative Treatment for Refractory REM Behavior Disorder in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri